Bacterial toxin and tissue culture / Loreny Gimenes Giugliano.

Por: Giugliano, Loreny GimenesColaborador(es):Drasar, Bohumil S [Orientador]Detalhes da publicação: London : [s.n.], 1983Notas: 152 f. : ilAssunto(s): Cultura de tecidos | Toxinas bacterianasClassificação Decimal de Dewey: 616.01 Nota de dissertação: Tese (Ph.D.) - University of London, 1983 Sumário: Tissue culture assays have recently been used in the study of diphtheria toxin, cholera enterotoxin and the heat-labile enterotoxin produced by Escherichia coli. The application of tissue culture assays to these toxins has contributed to our understanding of their mode of action. This thesis presents the results of a systematic investigation of the sensivity to bacterial toxins of cell lines in tissue culture. Attention was focused on those bacteria involved in diarrhoeal disease. The toxins investigated included those produced by Escherichia coli, Clostridium perfringens, Clostridium difficile, Bacillus cereus and bacteria isolated from cases of malabsorption. Two aspects of the problem were highlighted: (i) the use of tissue cultures for detection and assay of bacterial toxins, and (ii) the use of tissue culture for elucidation of the biochemical mechanisms of toxins. In addition to those cell lines reported by previous investigators to be sensitive to toxins.
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Tese T 616.01 G537b (Percorrer estante(Abre abaixo)) Disponível 00-1001

Tese (Ph.D.) - University of London, 1983

Tissue culture assays have recently been used in the study of diphtheria toxin, cholera enterotoxin and the heat-labile enterotoxin produced by Escherichia coli. The application of tissue culture assays to these toxins has contributed to our understanding of their mode of action. This thesis presents the results of a systematic investigation of the sensivity to bacterial toxins of cell lines in tissue culture. Attention was focused on those bacteria involved in diarrhoeal disease. The toxins investigated included those produced by Escherichia coli, Clostridium perfringens, Clostridium difficile, Bacillus cereus and bacteria isolated from cases of malabsorption. Two aspects of the problem were highlighted: (i) the use of tissue cultures for detection and assay of bacterial toxins, and (ii) the use of tissue culture for elucidation of the biochemical mechanisms of toxins. In addition to those cell lines reported by previous investigators to be sensitive to toxins.

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